Peer reviewed papers

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2024

148. Nigri M, Bramati G, Steiner AC, Wolfer DP. Appetitively motivated tasks in the IntelliCage reveal a higher motivational cost of spatial learning in male than female mice.
Front Behav Neurosci 29:1270159, 2024

147. Jaric I, Voelkl B, Amrein I, Wolfer DP, Novak J, Detotto C, Weber-Stadlbauer U, Meyer U, Manuella F, Mansuy IM, Würbel H. Using mice from different breeding sites fails to improve replicability of results from single-laboratory studies. Lab Anim (NY) 53:18-22, 2024

2023

146. Santhosh Kumar H, Moore J, Steiner AC, Sotirakis E, Schärli B, Isnard-Petit P, Thiam K, Wolfer DP, Böttger EC. Mistranslation-associated perturbations of proteostasis do not promote accumulation of amyloid beta and plaque deposition in aged mouse brain. Cell Mol Life Sci 80:378, 2023

145. Ma X, Schildknecht B, Steiner AC, Amrein I, Nigri M, Bramati G, Wolfer DP. Refinement of IntelliCage protocols for complex cognitive tasks through replacement of drinking restrictions by incentive-disincentive paradigms. Front Behav Neurosci 17:1256744, 2023

144. Jörimann M, Maliković J, Wolfer DP, Pryce CR, Endo T, Benner S, Amrein I. Bank voles show more impulsivity in IntelliCage learning tasks than wood mice. Neuroscience 510:157-170, 2023

143. Bramati G, Stauffer P, Nigri M, Wolfer DP, Amrein I. Environmental enrichment improves hippocampus-dependent spatial learning in female C57BL/6 mice in novel IntelliCage sweet reward-based behavioral tests. Front Behav Neurosci 17:1256744, 2023

142. Maliković J, Amrein I, Vinciguerra L, Lalošević D, Wolfer DP, Slomianka L.
Cell numbers in the reflected blade of CA3 and their relation to other hippocampal principal cell populations across seven species. Front Neuranat 16:1070035, 2023

2022

141. Erdinger S, Amrein I, Back M, Ludewig S, Korte M, von Engelhardt J, Wolfer DP, Müller UC.
Lack of APLP1 leads to subtle alterations in neuronal morphology but does not affect learning and memory. Front Mol Neurosci 15:1028836, 2022

140. Jaric I, Voelkl B, Clerc M, Schmid MW, Novak J, Rosso M, Rufener R, von Kortzfleisch VT, Richter SH, Buettner M, Bleich A, Amrein I, Wolfer DP, Touma C, Sunagawa S, Würbel H.
The rearing environment persistently modulates mouse phenotypes from the molecular to the behavioural level. PLoS Biol 20:e3001837, 2022

139. Brilkova M, Nigri M, Kumar HS, Moore J, Mantovani M, Keller C, Grimm A, Eckert A, Shcherbakov D, Akbergenov R, Seebeck P, Krämer SD, Wolfer DP, Gent TC, Böttger EC.
Error-prone protein synthesis recapitulates early symptoms of Alzheimer disease in aging mice.
Cell Rep 40:111433, 2022

138. Bold CS, Baltissen D, Ludewig S, Back MK, Just J, Kilian L, Erdinger S, Banicevic M, Rehra L, Almouhanna F, Nigri M, Wolfer DP, Spilger R, Rohr K, Kann O, Buchholz CJ, von Engelhardt J, Korte M, Müller UC. APPsα rescues Tau-induced synaptic pathology.
J Neurosci 42:5782-5802, 2022

137. Juskeviciene R, Fritz AK, Brilkova M, Akbergenov R, Schmitt K, Rehrauer H, Laczko E, Isnard-Petit P, Thiam K, Eckert A, Schacht J, Wolfer DP, Böttger EC, Shcherbakov D. Phenotype of Mrps5-associated phylogenetic polymorphisms is intimately linked to mitoribosomal misreading.
Int J Mol Sci 23:4384, 2022

136. Nigri M, Åhlgren J, Wolfer DP, Voikar V. Role of environment and experimenter in reproducibility of behavioral studies with laboratory mice. Front Behav Neurosci 16:e835444, 2022

135. Shcherbakov D, Nigri M, Akbergenov R, Brilkova M, Mantovani M, Petit PI, Grimm A, Karol AA, Teo Y, Sanchón AC, Kumar Y, Eckert A, Thiam K, Seebeck P, Wolfer DP, Böttger EC. Premature aging in mice with error-prone protein synthesis. Sci Adv 8:eabl9051, 2022

2021

134. Luo W, Egger M, Domonkos A, Que L, Lukacsovich D, Cruz-Ochoa NA, Szocs S, Seng C, Arszovszki A, Sipos E, Amrein I, Winterer J, Lukacsovich T, Szabadics J, Wolfer DP, Varga C,
Földy C. Recurrent rewiring of the adult hippocampal mossy fiber system by a single transcriptional regulator, Id2. PNAS 118:e2108239118, 2021

133. Moore J, Akbergenov R, Nigri M, Isnard-Petit P, Grimm A, Seebeck P, Restelli L, Frank S, Eckert A, Thiam K, Wolfer DP, Shcherbakov D, Böttger EC. Random errors in protein synthesis activate an age-dependent program of muscle atrophy in mice. Commun Biol 4:703, 2021

132. Steubler V, Erdinger S, Back MK, Ludewig S, Fässler D, Richter M, Han K, Slomianka L, Amrein I, von Engelhardt J, Wolfer DP, Korte M, Müller UC. Loss of all three APP family members during development impairs synaptic function and plasticity, disrupts learning, and causes an autism-like phenotype. EMBO J 40:e107471, 2021

131. Srimat Kandadai K, Kotur MB, Dokalis N, Amrein I, Keller CW, Münz C, Wolfer DP, Prinz M, Lünemann JD. ATG5 in microglia does not contribute vitally to autoimmune neuroinflammation in mice. Autophagy 17:3566-3576, 2021

2020

130. Mehr A, Hick M, Ludewig S, Müller M, Herrmann U, von Engelhardt J, Wolfer DP, Korte M, Müller UC. Lack of APP and APLP2 in GABAergic Forebrain Neurons Impairs Synaptic Plasticity and Cognition. Cereb Cortex 30:4044-4063, 2020

2019

129. Schelle J, Wegenast-Braun BM, Fritschi SK, Kaeser SA, Jährling N, Eicke D, Scodras A, Beschorner N, Obermueller U, Häsler LM, Wolfer DP, Mueggler T, Shimshek DR, Neumann U, Dodt HU, Staufenbiel M, Jucker M. Early Aβ reduction prevents progression of cerebral amyloid angiopathy. Ann Neurol 86:561-571, 2019

128. van Dijk RM, Wiget F, Wolfer DP, Slomianka L, Amrein I. Consistent within-group covariance of septal and temporal hippocampal neurogenesis with behavioral phenotypes for exploration and memory retention across wild and laboratory
small rodents. Behav Brain Res 372:112034, 2019

127. Festa BP, Berquez M, Gassama A, Amrein I, Ismail HM, Samardzija M, Staiano L, Luciani A, Grimm C, Nussbaum RL, De Matteis MA, Dorchies OM, Scapozza L, Wolfer DP, Devuyst O. OCRL Deficiency Impairs Endolysosomal Function in a Humanized Mouse Model for Lowe Syndrome and Dent Disease. Hum Mol Genet 28:1931-1946, 2019

126. Boeddrich A, Babila JT, Wiglenda T, Diez L, Jacob M, Nietfeld W, Huska MR, Haenig C, Groenke N, Buntru A, Blanc E, Meier JC, Vannoni E, Erck C, Friedrich B, Martens H, Neuendorf N, Schnoegl S, Wolfer DP, Loos M, Beule D, Andrade-Navarro MA, Wanker EE. The Anti-amyloid Compound DO1 Decreases Plaque Pathology and Neuroinflammation-Related Expression Changes in 5xFAD Transgenic Mice. Cell Chem Biol 26:109-120, 2019

2018

125. Akbergenov R, Duscha S, Fritz AK, Juskeviciene R, Oishi N, Schmitt K, Shcherbakov D, Teo Y, Boukari H, Freihofer P, Isnard-Petit P, Oettinghaus B, Frank S, Thiam K, Rehrauer H, Westhof E, Schacht J, Eckert A, Wolfer DP, Böttger EC. Mutant MRPS5 affects mitoribosomal accuracy and confers stress-related behavioral alterations. EMBO Rep 19:e46193, 2018

124. Roccaro-Waldmeyer DM, Girard F, Milani D, Vannoni E, Prétôt, Wolfer DP, Celio MR. Eliminating the VGlut2-dependent glutamatergic transmission of parvalbumin-expressing neurons leads to deficits in locomotion and vocalization, decreased pain sensitivity, and increased dominance. Front Behav Neurosci 12:146, 2018

123. Berry S, Weinmann O, Fritz AK, Rust R, Wolfer DP, Schwab ME, Gerber U, Ster J. Loss of Nogo-A, encoded by the schizophrenia risk gene Rtn4, reduces mGlu3 expression and causes hyperexcitability in hippocampal CA3 circuits. PLoS One 13:e0200896, 2018

122. Richter MC, Ludewig S, Winschel A, Abel T, Bold C, Slazburger LR, Klein S, Han K, Weyer S, Fritz AK, Laube B, Wolfer DP, Buchholz CJ, Korte M, Müller UC. Distinct in vivo role of APPsα versus APPsβ for spine density, synaptic plasticity and cognition. EMBO J 37:e98335, 2018

121. Stieglitz MS, Fenske S, Hammelmann V, Becirovic E, Schöttle V, Delorme JE, Schöll-Weidinger M, Mader R, Deussing J, Wolfer DP, Seeliger MW, Albrecht U, Wotjak CT, Biel M, Michalakis S, Wahl-Schott C. Disturbed processing of contextual information in HCN3 channel deficient mice.
Front Mol Neurosci 10:436, 2018

120. Voikar V, Krackow S, Lipp HP, Rau A, Colacicco G, Wolfer DP. Automated dissection of permanent effects of hippocampal or prefrontal lesions on performance at spatial, working memory and circadian timing tasks of C57BL/6 mice in IntelliCage. Behav Brain Res 352:8-22, 2018

2017

119. Basler L, Gerdes S, Wolfer DP, Slomianka L.
Sampling the mouse hippocampal dentate gyrus. Front Neuroanat 11:123, 2017

118. Fritz AK, Amrein I, Wolfer DP. Similar reliability and equivalent performance of female and male mice in the open field and water-maze place navigation task.
Am J Med Genet C 175:380-391, 2017

117. Alboni S, van Dijk M, Poggini S, Giampaolo M, Perrotta ML, Drenth T, Brunello N, Wolfer DP, Limatola C, Amrein I, Cirulli F, Maggi L, Branchi I. Fluoxetine effects on molecular, cellular and behavioral endophenotypes of depression are driven by the living environment.
Mol Psychiatry 22:552-561, 2017

116. Mundwiler J, Schüpbach U, Dieterle T, Leuppi JD, Schmidt-Trucksäss A, Wolfer DP,
Miedinger D, Brighenti-Zogg S. Association of occupational and leisure-time physical activity
with aerobic capacity in a working population. PLoS One 12:e0168683, 2017

2016

115. Alboni S, Poggini S, Garofalo S, Milior G, El Hajj H, Lecours C, Girard I, Gagnon S, Boisjoly-Villeneuve S, Brunello N, Wolfer DP, Limatola C, Tremblay MÈ, Maggi L, Branchi I. Fluoxetine treatment affects the inflammatory response and microglial function according to the quality of the living environment. Brain Behav Immun 58:261-271, 2016

114. Brighenti-Zogg S, Mundwiler J, Schüpbach U, Dieterle T, Wolfer DP, Leuppi JD, Miedinger D. Physical workload and work capacity across occupational groups. PLoS One 11:e0154073, 2016

113. van Dijk RM, Lazic SE, Slomianka L, Wolfer DP, Amrein I. Large scale phenotyping links adult hippocampal neurogenesis to the reaction to novelty. Hippocampus 26:646-657, 2016

2015

112. Mircsof D, Langouët M, Rio M, Moutton S, Siquier-Pernet K, Bole-Feysot C, Cagnard N, Nitschke P, Gaspar L, Znidaric M, Alibeu O, Fritz AK, Wolfer DP, Schröter A, Bosshard G, Rudin M, Koester C, Crestani D, Seebeck P, Boddaert N, Prescott K, DDD study, Hines R, Moss SJ, Fritschy JM, Munnich A, Amiel J, Brown SA, Tyagarajan SK, Colleaux L. Mutations in NONO are a novel cause of syndromic intellectual disability and inhibitory synaptic defects. Nat Neurosci 18:1731-1736, 2015

111. Klevanski M, Herrmann U, Weyer SW, Fol R, Cartier N, Wolfer DP, Caldwell JH, Korte M, Müller UC. The APP intracellular domain is required for normal synaptic morphology, synaptic plasticity and hippocampus dependent behavior. J Neurosci 35:16018-16033, 2015

110. Lang UE, Ackermann TF, Wolfer DP, Schubert F, Sohr R, Hörtnagl H, Lang F, Gallinat J. Phosphoinositide-dependent protein kinase 1 (PDK1): impact on schizophrenia risk and endophenotype profile. Z Pychologie 223:165-172, 2015

109. Huang S, Slomianka L, Farmer AJ, Kharlamova AV, Gulevich RG, Herbeck YE, Trut LN, Wolfer DP, Amrein I. Selection for tameness, a key behavioral trait of domestication, increases adult hippocampal neurogenesis in foxes. Hippocampus 25:963-975, 2015

108. Wöhr M, Orduz D, Gregory P, Moreno H, Khan U, Vörckel KJ, Wolfer DP, Welzl H, Gall D, Schiffmann S, Schwaller B. Lack of parvalbumin in mice leads to behavioral deficits relevant to all human autism core symptoms and related neural morpho-functional abnormalities.
Transl Psych 5:e525, 2015

107. Hick M, Herrmann U, Weyer SW, Mallm P, Tschäpe J, Borgers M, Mercken M, Roth R, Draguhn A, Slomianka L, Wolfer DP, Korte M, Müller UC. Acute function of secreted Amyloid Precursor Protein fragment APPsα in synaptic plasticity. Acta Neuropathol 129:21-37, 2015

2014

106. Gapp K, Soldado-Magraner S, Alvarez-Sánchez M, Bohacek J, Vernaz G, Shu H, Franklin TB, Wolfer DP, Mansuy IM.Early life stress in fathers improves behavioural flexibility in their offspring.
Nat Commun 5:5466, 2014

105. Blaser N, Guskov SI, Entin VA, Wolfer DP, Kanevskyi VA, Lipp HP. Gravity anomalies without geomagnetic disturbances interfere with pigeon homing - a GPS tracking study.
J Exp Biol 217:4057-4067, 2014

104. Vannoni E, Voikar V, Colacicco G, Alvarez-Sánchez M, Lipp HP, Wolfer DP. Spontaneous behavior in the social homecage discriminates strains, lesions and mutations in mice.
J Neurosci Meth 234:26-37, 2014

103. Corradini I, Donzelli A, Antonucci F, Welzl H, Loos M, Martucci R, De Astis S, Pattini L, Inverardi F, Wolfer DP, Caleo M, Bozzi Y, Verderio C, Frassoni C, Braida D, Clerici M, Lipp HP, Sala M, Matteoli M. Epileptiform activity and cognitive deficits in SNAP-25+/- mice are normalized by antipeileptic drugs. Cerebral Cortex 24:364-376, 2014

2013

102. Albuquerque B, Häussler A, Vannoni E, Wolfer DP, Tegeder I. Learning and memory in mice with neuropathic pain: impact of old age and progranulin deficiency.
Front Behav Neurosci 7:174, 2013

101. Blaser N, Dell'omo G, Dell'ariccia G, Wolfer DP, Lipp HP. Testing cognitive navigation in unknown territories: homing pigeons choose different targets. J Exp Biol 216:3123-3131, 2013

100. Kobayashi Y, Sano Y, Vannoni E, Goto H, Suzuki H, Oba A, Kawasaki H, Kanba S, Lipp HP, Murphy NP, Wolfer DP, Itohara S. Genetic dissection of medial habenula-interpeduncular nucleus pathway function in mice. Front Behav Neurosci 7:17, 2013

2012

99. Singer D, Camargo SM, Ramadan T, Schäfer M, Mariotta L, Herzog B, Huggel K, Wolfer DP, Werner S, Penninger JM, Verrey F. Defective intestinal amino acid absorption in Ace2 null mice.
Am J Physiol Gastrointest Liver Physiol 303:G686-G695, 2012

98. Codita A, Mohammed AH, Willuweit A, Reichelt A, Alleva E, Branchi I, Cirulli F, Colacicco G, Voikar V, Wolfer DP, Buschmann FJ, Lipp HP, Vannoni E, Krackow S. Effects of Spatial and Cognitive Enrichment on Activity Pattern and Learning Performance in Three Strains of Mice in the IntelliMaze. Behav Genet 42:449-460, 2012

97. Ramakers GJA, Wolfer DP, Rosenberger G, Kuchenbecker K, Kreienkamp HJ, Prange-Kiel J, Rune G, Richter K, Langnaese K, Masneuf S, Bösl MR, Fischer KD, Krugers HJ, Lipp HP, van Galen E, Kutsche K. Dysregulation of Rho GTPases in the alphaPix/Arhgef6 mouse model of X-linked intellectual disability is paralleled by impaired structural and synaptic plasticity and cognitive deficits.
Hum Mol Genet 21:268-286, 2012

2011

96. d'Isa R, Clapcote SJ, Voikar V, Wolfer DP, Giese KP, Brambilla R, Fasano S. Mice lacking Ras-GRF1 show contextual fear conditioning but not spatial memory impairments: convergent evidence from two independently generated mouse mutant lines. Front Behav Neurosci 5:78, 2011

95. Weyer SW, Klevanski M, Delekate A, Voikar V, Aydin D, Hick M, Filippov M, Drost N, Schaller KL, Saar M, Vogt MA, Gass P, Samanta A, Jäschke A, Korte M, Wolfer DP, Caldwell JH, Müller UC. APP and APLP2 are essential at PNS and CNS synapses for transmission, spatial learning and LTP.
EMBO J 30:2266-2280, 2011

94. Endo T, Maekawa F, Võikar V, Haijima A, Uemura Y, Zhang Y, Miyazaki W, Suyama S, Shimazaki K, Wolfer DP, Yada T, Tohyama C, Lipp HP, Kakeyama M. Automated test of behavioral flexibility in mice using a behavioral sequencing task in IntelliCage. Behav Brain Res 221:172-181, 2011

93. Richter SH, Garner JP, Zipser B, Lewejohann L, Sachser N, Touma C, Schindler B, Chourbaji S, Brandwein C, Gass P, van Stipdonk N, van der Harst J, Spruijt B, Võikar V. Wolfer DP, Wurbel H. Effect of population heterogenization on the reproducibility of mouse behavior: a multi-laboratory study. PLoS ONE 6:e16461, 2011

2010

92. Shimokawa N, Haglund K, Hölter SM, Grabbe C, Kirkin V, Koibuchi N, Schultz C, Rozman J, Hoeller D, Qiu CH, Londoño MB, Ikezawa J, Jedlicka P, Stein B, Schwarzacher SW, Wolfer DP, Ehrhardt N, Heuchel R, Nezis I, Brech A, Schmidt MHH, Fuchs H, Gailus-Durner V, Klingenspor M, Bogler O, Wurst W, Deller T, Hrabé de Angelis M, Dikic I. CIN85 regulates dopamine receptor endocytosis and governs behavior in mice. EMBO J 29:2421-2432, 2010

91. Voikar V, Colacicco G, Gruber O, Vannoni E, Lipp HP, Wolfer DP. Conditioned response suppression in the IntelliCage: assessment of mouse strain differences and effects of hippocampal and striatal lesions on acquisition and retention of memory. Behav Brain Res 213:304-312, 2010

90. Althoff GEM, Wolfer DP, Timmesfeld N, Kanzler B, Schrewe H, Pagenstecher A. Long-term expression of TIMP1 in the murine CNS does not alter the morphological and behavioural phenotype but alleviates the course of EAE. Am J Pathol 177:840-853, 2010

89. Coomaraswamy J, Kilger E, Wölfing H, Schäfer C, Kaeser SA, Wegenast-Braun BM, Hefendehl JK, Wolburg H, Mazzella M, Ghiso J, Goedert M, Akiyama H, Garcia-Sierra F, Wolfer DP, Mathews PM, Jucker M. Modeling familial Danish dementia in mice supports the concept of the amyloid hypothesis of Alzheimer's disease. PNAS 107:7969-7974, 2010

88. Krackow S, Vannoni E, Codita A, Mohammed AH, Cirulli F, Branchi I, Alleva E, Reichelt A, Willuweit A, Voikar V, Colacicco G, Wolfer DP, Buschmann JUF, Safi K, Lipp HP. Consistent behavioral phenotype differences between inbred mouse strains in the IntelliCage.
Genes Brain Behav 9:722–731, 2010

2009

87. Vyssotski AL, Dell’Omo G, Dell’Ariccia G, Abramchuk AN, Serkov AN, Latanov AV, Loizzo A, Wolfer DP, Lipp HP. EEG responses to visual landmarks in flying pigeons.
Curr Biol 19:1159-1166, 2009

86. Mohajeri MH, Wolfer DP. Neprilysin deficiency-dependent impairment of cognitive functions in a mouse model of amyloidosis. Neurochem Res 34:717-726, 2009

2008

85. Ackermann TF, Hörtnagl H, Wolfer DP, Colacicco G, Sohr R, Lang F, Hellweg R, Lang UE. Phosphatidylinositide dependent kinase deficiency increases anxiety and decreases GABA
and serotonin abundance in the amygdala.
Cell Physiol Biochem 22:745-754, 2008

84. Dell'Ariccia G, Dell'Omo G, Wolfer DP, Lipp HP. Flock flying improves pigeon's homing: GPS track analysis of individual flyers versus small groups.
Anim Behav 76:1165-1172, 2008

83. Kilic E, Kilic U, Bacigaluppi M, Guo Z, Ben Abdallah N, Wolfer DP, Reiter RJ, Hermann DM, Bassetti CL. Delayed melatonin administration promotes neuronal survival, neurogenesis and motor recovery, and attenuates hyperactivity and anxiety after mild focal cerebral ischemia in mice.
J Pineal Res 45:142-148, 2008

2007

82. Ring S, Weyer S, Kilian SB, Waldron E, Pietrzik CU, Filippov M, Herms J, Buchholz C, Eckman CB, Korte M, Wolfer DP, Muller UC. The secreted APPsalpha domain is sufficient to rescue the anatomical, behavioral, and electrophysiological abnormalities of APP deficient mice.
J Neurosci 27:7817-7826, 2007

81. Daumas S, Betourne A, Halley H, Wolfer DP, Lipp HP, Lassalle JM, Francés B. Transient activation of the CA3 Kappa opioid system in the dorsal hippocampus impairs complex memory processing in mice. Neurobiol Learn Mem 88:94-103, 2007

80. Farré-Castany MA, Schwaller B, Gregory P, Jaroslaw B, Mariethoz C, Erikson J, Tetko IV,
Wolfer DP, Schmutz I, Albrecht U, Villa AE. Differences in locomotor behavior revealed in mice deficient for the calcium-binding proteins parvalbumin, calbindin-D28k or both.
Behav Brain Res 178:250-261, 2007

79. Poirier R, Jacquot S, Vaillend C. Soutthiphong AA, Libbey M, Davis S, Laroche S, Hanauer A, Welzl H, Lipp HP, Wolfer DP. Deletion of the Coffin-Lowry syndrome gene Rsk2 in mice is
associated with impaired spatial learning and reduced control of
exploratory behavior. Behav Genet 37:31-50, 2007

2006

78. Plath N, Ohana O, Dammermann B, Errington ML, Gross C, Mao X, Engelsberg A, Mahlke C, Welzl H, Kobalz U, Stawrakakis A, Fernandez E, Waltereit R, Bick-Sander A, Therstappen E, Cooke SF, Blanquet V, Wurst W, Salmen B, Bosl MR, Lipp HP, Schmitz D, Grant SGN, Bliss TVP, Wolfer DP, Kuhl D.
Arg3.1/Arc is essential for the consolidation of synaptic plasticity and memories. Neuron 52:437-444, 2006

77. Ackermann GE, Marenholz I, Wolfer DP, Chan WY,
Schäfer B, Erne P, Heizmann CW. S100A1 is involved in mouse exploratory and anxiety-like behavior.
Biochim Biophys Acta 1763:1307-1319, 2006

76. Madani R, Poirier R, Wolfer DP, Welzl H, Groscurth P, Lipp HP, Lu B, El Mouedden M,
Mercken M, Nitsch RM, Mohajeri MH. Lack of neprilysin suffices to generate murine amyloid-like deposits in the brain and behavioral deficit in vivo. Neurosci Res 84:1871-1878, 2006

75. Poirier R, Wolfer DP, Welzl H, Tracy J, Galsworthy MJ, Nitsch RM, Mohajeri MH. Neuronal neprilysin overexpression is associated with attenuation of Aβ-related spatial memory deficit. Neurobiol Dis 24:475-483, 2006

74. Pennanen L, Wolfer DP, Nitsch RM, Gotz J. Impaired spatial reference memory and increased exploratory behavior in P301L tau transgenic mice. Genes Brain Behav 5:239-379, 2006

73. Heinicke K, Baum O, Ogunshola OO, Vogel J, Stallmach T, Wolfer DP, Keller S, Weber K, Wagner PD, Gassmann M, Djonov V. Excessive erythrocytosis in adult mice overexpressing erythropoietin leads to hepatic, renal, neuronal and muscular degeneration. Am J Physiol Regul Integr Comp Physiol 291:R947-956, 2006

72. Berger S, Wolfer DP, Selbach O, Alter H, Erdmann G, Reichhardt, HM, Chepkova AN, Welzl H, Haas HL, Lipp HP, Schutz G. Loss of the limbic mineralocorticoid receptor impairs behavioral plasticity. PNAS 103:195-200, 2006

71. Vyssotski AL, Serkov AN, Itskov PM, Dell’Omo G, Latanov AV, Wolfer DP, Lipp HP. Miniature neurologgers for flying pigeons: multichannel EEG, action and field potentials in combination with GPS recording. J Neurophysiol 95:1263-1273, 2006

70. Lang UE*, Wolfer DP*, Grahammer F, Strutz-Seebohm N, Seebohm G, Lipp HP, McCormick JA, Hellweg R, Dawson K, Wang J, Pearce D, Lang F. Reduced locomotion in the serum and glucocorticoid inducible kinase 3 knock out mouse. Behav Brain Res 167:75-86, 2006 * equal contribution

69. Zueger M, Urani A, Chourbaji S, Zacher C, Lipp HP, Albrecht U, Spanagel R, Wolfer DP, Gass P. mPer1 and mPer2 mutant mice show regular spatial and contextual learning in standardized tests for hippocampus-dependent learning. J Neural Transm 113:347-356, 2006

2005

68. Dong Z, Wolfer DP, Lipp HP, Büeler H. Hsp70 gene transfer by adeno-associated virus inhibits MPTP-induced nigrostriatal degeneration in the mouse model of Parkinson’s disease. Mol Ther 11:80-88, 2005

2004

67. Wolfer DP, Litvin O, Morf S, Nitsch RM, Lipp HP, Wurbel H. Laboratory animal welfare: cage enrichment and mouse behaviour. Nature 432:821-822, 2004

66. Lipp HP, Vyssotski AL, Wolfer DP, Renaudineau S, Savini S, Tröster G, Dell'Omo, G. Pigeon homing along highways and exits. Curr Biol 14:1239-1249, 2004

65. Raivich G, Bohatschek M, DaCosta C, Iwata O, Galiano M, Hristova M, Nateri AS, Makwana M, Riera-Sans L, Wolfer DP, Lipp HP, Aguzzi A, Wagner EF, Behrens A. The AP-1 transcription factor c-Jun is required for efficient axonal regeneration. Neuron 43:57-67, 2004

64. Sausbier M, Hu H, Arntz C, Feil S, Kamm S, Adelsberger H, Sausbier U, Sailer CA, Feil R, Hofmann F, Korth M, Shipston MJ, Knaus HG, Wolfer DP, Pedroarena CM, Storm JF, Ruth P. Cerebellar ataxia and Purkinje cell dysfunction caused by Ca2+-activated K+ channel deficiency. PNAS 101:9474-9478, 2004

63. Harvey RJ, Depner UB, Wässle H, Ahmadi S, Heindl C, Reinold H, Smart TG, Harvey K, Schütz B, Abo-Salem OM, Zimmer A, Poisbeau P, Welzl H, Wolfer DP, Betz H, Zeilhofer HU, Müller U. GlyR alpha3: an essential target for spinal PGE2-mediated iInflammatory pain sensitization. Science 304:884-887, 2004

62. Mohajeri MH, Madani R, Saini K, Lipp HP, Nitsch RM, Wolfer DP. The impact of the genetic background on the neurodegeneration and behavior in seizured mice. Genes Brain Behav 3:228-239, 2004

61. D'Adamo P, Wolfer DP, Kopp C, Tobler I, Toniolo D, Lipp HP. Mice deficient for the synaptic vesicle protein Rab3a show impaired spatial reversal learning and increased explorative activity but none of the behavioral changes shown by mice deficient for the Rab3a regulator Gdi1. Eur J Neurosci 19:1895-1905, 2004

60. Korbo L, Amrein I, Lipp HP, Wolfer DP, Regeur L, Oster S, Pakkenberg B. No evidence for loss of hippocampal neurons in non-Alzheimer dementia patients. Acta Neurol Scand 109:132-139, 2004

2003

59. Zörner B*, Wolfer DP*, Brandis D, Kretz O, Zacher C, Madani R, Grunwald I, Lipp HP, Klein R, Henn FA, Gass P. Forebrain-specific trkB-receptor knock-out mice: behaviorally more hyperactive than "depressive". Biol Psychiatry 54:972-982, 2003 * equal contribution

58. Balschun D*, Wolfer DP*, Gass P, Mantamadiotis T, Welzl H, Schütz G, Frey JU, Lipp HP. Does CREB have a pivotal role in hippocampal synaptic plasticity and hippocampus-dependent memory? J Neurosci 23:6304-6314, 2003 * equal contribution

57. Lang UE, Lang F, Richter K, Vallon V, Lipp HP, Schnermann J, Wolfer DP. Emotional instability but intact spatial cognition in adenosine receptor 1 knock-out mice. Behav Brain Res 145:179-188, 2003

56. Madani R, Kozlov S, Akhmedov A, Cinelli P, Kinter J, Lipp HP, Sonderegger P, Wolfer DP. Impaired explorative behavior and neophobia in genetically modified mice lacking or overexpressing the extracellular serine protease inhibitor neuroserpin. Mol Cell Neurosci 23:473-494, 2003

55. Mohajeri MH, Saini K, Li H, Crameri A, Lipp HP, Wolfer DP, Nitsch RM. Intact spatial memory in mice with seizure-induced partial loss of hippocampal pyramidal neurons. Neurobiol Dis 12:174-181, 2003

54. Dell'Omo G, Pleskacheva MG, Wolfer DP, Lipp HP, Shore RF. Comparative effects of exposure to an organophosphate pesticide on locomotor activity of laboratory mice and five species of wild rodents. Bull Environ Contam Toxicol 70:138-145, 2003

2002

53. Pleskacheva MG, Zorina ZA, Nikolenko DL, Wolfer DP, Kostyna ZA, Lipp HP. Behavioral impairments in Morris water maze in rats selectively bred for audiogenic seizure susceptibility (Krushinsky-Molodkina strain).
Zh Vyssh Nerv Deiat Im I P Pavlova 52:356-365, 2002

52. D’Adamo P, Welzl H, Papadimitriou S, Raffaele di Barletta M, Tiveron C, Tatangelo L, Pozzi L, Chapman PF, Knevett SG, Ramsay MF, Valtorta F, Leoni C, Menegon A, Wolfer DP, Lipp HP, Toniolo D. Deletion of the mental retardation gene Gdi1 impairs associative memory and alters social behavior in mice. Hum Mol Genet 11:2567-2580, 2002

51. Tremml P, Lipp HP, Muller U, Wolfer DP. Enriched early experiences of mice underexpressing the ß-amyloid precursor protein restore spatial learning capabilities but not normal openfield behavior of adult animals. Genes Brain Behav 1:230-241, 2002

50. Mazzucchelli C, Vantaggiato C, Ciamei A, Fasano S, Pakhotin P, Krezel V, Welzl H, Wolfer DP, Pages G, Valverde O, Marowsky A, Porrazzo A, Orban PC, Maldonado R, Ehrengruber MU, Cestari V, Lipp HP, Chapman PF, Pouyssegur J, Brambilla R. Knockout of ERK1 MAP kinase enhances synaptic plasticity in the striatum and facilitates striatal-mediated learning and memory. Neuron, 34:807-820, 2002

49. Vyssotski AL, Dell'Omo G, Poletaeva II, Vyssotski DL, Minichiello L, Klein R, Wolfer DP, Lipp HP. Long-term monitoring of hippocampus-dependent behavior in naturalistic settings: mutant mice lacking the neurotrophin receptor TrkB in the forebrain show spatial learning but impaired behavioral flexibility. Hippocampus 12:27-38, 2002

2001

48. Grunwald IC, Korte M, Wolfer DP, Wilkinson GA, Unsicker K, Lipp HP, Bonhoeffer T, Klein R. Kinase-independent requirement of EphB2 receptors in hippocampal synaptic plasticity. Neuron 32:1027-1040, 2001

47. Wolfer DP, Lang R, Cinelli, P, Madani, R, Sonderegger P. Multiple roles of neurotrypsin in tissue morphogenesis and nervous system development suggested by the mRNA expression pattern. Mol Cell Neurosci 18:407-433, 2001

46. Valenti P, Cozzio A, Nishida N, Wolfer DP, Sakagushi S, Lipp HP. Similar target, different effects: late-onset ataxia and spatial learning in Prion protein deficient mouse lines. Neurogenetics 3:173-184, 2001

45. Otto C, Martin M, Wolfer DP, Lipp HP, Maldonado R, Schütz G. Altered emotional behavior in PACAP-type-I-receptor-deficient mice. Mol Brain Res 92:78-84, 2001

44. Wolfer DP, Madani R, Valenti P, Lipp HP. Extended analysis of path data from mutant mice using the public domain software Wintrack. Physiol Behav 73:745-753, 2001

43. Henion TR, Zhou D, Wolfer DP, Jungalwala FB, Hennet T. Cloning of a mouse beta1 3 N-acetylglucosaminyltransferase Lc3 synthase gene encoding the key regulator of lacto-series glycolipid biosynthesis. J Biol Chem 276:30261-30269, 2001

42. Otto C, Kovalchuk Y, Wolfer DP, Gass P, Martin M, Zuschratter W, Gröne HJ, Kellendonk C, Tronche F, Maldonado R, Lipp HP, Konnerth A, Schütz G. Impairment of mossy fiber LTP and associative learning in PACAP-type-I-receptor-deficient mice. J Neurosci 21:5520-5527, 2001

41. Sauder C, Wolfer DP, Lipp HP, Staeheli P, Hausmann J. Learning deficits in mice with persistent Borna disease virus infection of the CNS associated with elevated chemokine expression. Behav Brain Res 120:189-201, 2001

2000

40. Steiner I, Bürgi C, Werffeli S, Dell'Omo G, Valenti P, Tröster G, Wolfer DP, Lipp HP. A GPS logger and software for analysis of homing in pigeons and small mammals. Physiol Behav 71:589-596, 2000

39. Gass P, Kretz O, Wolfer DP, Berger S, Tronche F, Reichardt HM, Kellendonk C, Lipp HP, Schmid W, Schütz G. Genetic disruption of mineralocorticoid receptor leads to impaired neurogenesis and granule cell degeneration in the hippocampus of adult mice. EMBO Rep 1:447-451, 2000

38. Heber S, Herms J, Gajic V, Hainfeller J, Aguzzi A, Rülicke T, Kretzschmar H, von Koch C, Sisodia S, Tremml P, Lipp HP, Wolfer DP, Müller U. Mice with combined gene knockouts reveal essential and partially reduntant functions of APP-family members. J Neurosci 20:7951-7963, 2000

37. Dell'Omo G, Ricceri L, Wolfer DP, Poletaeva II, Lipp HP. Temporal and spatial adaptation to food restriction in mice under naturalistic conditions. Behav Brain Res 115:1-8, 2000

36. Stork O, Welzl H, Wolfer DP, Schuster T, Mantei N, Stork S, Hoyer D, Lipp H. -P, Obata K, Schachner M. Recovery of emotional behaviour in NCAM null mutant mice through transgenic expression of NCAM180.
Eur J Neurosci 12:3291-3306, 2000

35. Chrast R, Scott HS, Madani R, Huber L, Wolfer DP, Prinz M, Aguzzi A, Lipp HP, Antonarakis SE. Mice trisomic for a bacterial artificial chromosome with the single-minded 2 gene (Sim2) show phenotypes similar to some ot those present in the partial trisomy 16 mouse models of Down syndrome. Hum Mol Genet 9:1853-1864, 2000

34. Pleskacheva MG, Wolfer DP, Kupriyanova IE, Nikolenko DL, Scheffrahn H, Dell'Omo G, Lipp HP. Hippocampal mossy fibers and swimming navigation learning in two vole species occupying different habitats. Hippocampus 10:17-30, 2000

1999

33. Balschun D, Wolfer DP, Bertocchini F, Barone S, Conti A, Zuschratter W, Missiaen L, Lipp HP, Sorrentino V. Deletion of ohe ryanodine receptor type 3 (RyR3) impairs forms of synaptic plasticity and spatial learning. EMBO J 18:5264-5273, 1999

32. Magara F, Müller U, Li ZW, Lipp HP, Weissmann C, Stagljar M, Wolfer DP. Genetic background changes the pattern of forebrain commissure defects in transgenic mice underexpressing the beta-amyloid-precursor protein. PNAS 96:4656-4661, 1999

31. Minichiello L, Korte M, Wolfer DP, Kühn R, Unsicker K, Cestari V, Rossi-Arnaud C, Lipp HP, Bonhoeffer T, Klein R. Essential role for TrkB receptors in hippocampus-mediated learning. Neuron 24:401-414, 1999

30. Phinney AL, Calhoun ME, Wolfer DP, Lipp, HP, Zheng H, Jucker, M. No hippocampal neuron or synaptic bouton loss in learning-impaired aged beta-amyloid precursor protein-null mice. Neuroscience 90:1204-1216, 1999

1998

29. Gass P, Wolfer DP, Balschun D, Rudolph D, Frey U, Lipp HP, Schütz G. Deficits in memory tasks of mice with CREB mutations depend on gene dosage. Learn Mem 5:274-288, 1998

28. Lipp HP, Stagliar M, Fischer M, Wolfer DP. A two-year longitudinal study of swimming navigation in mice devoid of the prion protein: no evidence for neurological anomalies or learning impariments. Behav Brain Res 95:47-54, 1998

27. Tremml P, Lipp HP, Müller U, Ricceri L, Wolfer DP. Neurobehavioral development, adult openfield exploration and swimming navigation learning in mice with a modified ß-amyloid precursor protein gene.
Behav Brain Res 95:65-76, 1998

26. Magara F, Welker E, Wolfer DP, Drescher-Lindh I. Lipp HP. Increased asymmetries in 2-deoxyglucose uptake in the brain of freely moving congenitally acallosal mice. Neuroscience 87:243-254, 1998

25. Wolfer DP, Mohajeri HM, Lipp HP, Schachner M. Increased flexibility and selectivity in spatial learning of transgenic mice ectopically expressing the neural cell adhesion molecule L1 in astrocytes. Eur J Neurosci 10:708-717, 1998

24. Wolfer DP, Giger RJ, Stagliar M, Sonderegger P, Lipp HP. Expression of the axon growth-related neural adhesion molecule TAG-1/axonin-1 in the adult mouse brain. Anat Embryol 197:177-185, 1998

1997

23. Gschwend TP, Krueger SR, Kozlov SV, Wolfer DP, Sonderegger P. Neurotrypsin, a novel multidomain serine protease expressed in the nervous system. Mol Cell Neurosci 9:207-219, 1997

22. Krueger SR, Ghisu GP, Cinelli P, Gschwend TP, Osterwalder T, Wolfer DP, Sonderegger P. Expression of neuroserpin, an inhibitor of tissue plasminogen activator, in the developing and adult nervous system of the mouse. J Neurosci 17:8984-8996, 1997

21. Monaghan AP, Bock D, Gass P, Schwäger A, Wolfer DP, Lipp HP, Schütz G. Defective limbic system in mice lacking the tailless gene. Nature 390:515-517, 1997

20. Brambilla R, Gnesutta N, Minichiello L, White G, Roylance AJ, Herron CE, Ramsey M, Wolfer DP, Cestari V, Rossi-Arnaud C, Grant SGN, Chapman PF, Lipp HP, Sturani E, Klein R. . A role for the RAS signaling pathway in synaptic transmission and long-term memory. Nature 390:281-286, 1997

19. Wolfer DP, Müller U, Stagliar M, Lipp HP. Assessing the effects of the 129/Sv genetic background on swimming navigation learning in transgenic mutants: a study using mice with a modified ß-amyloid precursor protein gene. Brain Res 771:1-13, 1997

1996

18. Giger RJ, Wolfer DP, de Wit GMJ, Verhaagen J. Anatomy of rat semaphorin-III/collapsin-1 mRNA expression and relationship to developing nerve tracts during neuroembryogenesis. J Comp Neurol. 375:378-392, 1996

17. Hausheer-Zarmakupi Z, Wolfer DP, Leisinger-Trigona MC, Lipp HP. Selective breeding for extremes in open-field activity of mice entails a differentiation of hippocampal mossy fibers. Behav Genet 26:167-176, 1996

16. Huang YY, Bach ME, Lipp HP, Zhuo M, Wolfer DP, Hawkins RD, Schoonjans L, Kandel ER, Godfraind JM, Mulligan R, Collen D, Carmeliet P. Mice lacking the gene encoding tissue-type plasminogen activator show a selective interference with late-phase long-term potentiation in both Schaffer collateral and mossy fiber pathways. PNAS 93:8699-8704, 1996

15. Lipp HP, Collins RL, Hausheer-Zarmakupi Z, Leisinger-Trigona MC, Crusio WE, Nosten-Bertrand M, Schwegler G, Wolfer DP. Paw preference and intra/infrapyramidal mossy fibers in the hippocampus of the mouse. Behav Genet 26:379-390, 1996

14. Müller U, Cristina N, Li ZW, Wolfer DP, Lipp HP, Rülicke T, Brandner S, Aguzzi A, Weissman C. Mice homozygous for a modified ß-amyloid precursor protein (ßAPP) gene show impaired behavior and high incidence of agenesis of the corpus callosum. Ann NY Acad Sci 777:65-73, 1996

1995

13. Dell'Omo G, Wolfer DP, Alleva, E, Lipp, HP. Developmental exposure to ozone induces subtle changes in swimming navigation of adult mice. Toxicol Lett 81:91-99, 1995

12. Giger RJ, Vogt L, Zuellig RA, Rader C, Henehan-Beatty A, Wolfer DP, Sonderegger P. The gene of chicken axonin-1: complete structure and analysis of the promoter. Eur J Biochem 22:617-628, 1995

11. Wolfer DP, Lipp HP. Evidence for physiological growth of hippocampal mossy fiber collaterals in the guinea pig during puberty and adulthood. Hippocampus 5:329-340, 1995

1994

10. Leitinger B, Poletaeva II, Wolfer DP, Lipp HP. Swimming navigation, open-field activity, and extrapolation behavior of two inbred mouse strains with Robertsonian translocation of chormosomes 8 and 17. Behav Genet 24:273-284, 1994

9. Bernasconi-Guastalla S, Wolfer DP, Lipp HP. Hippocampal mossy fibers and swimming navigation in mice: the influence of size and left-right asymmetries. Hippocampus 4:53-64, 1994

8. Müller U, Cristina N, Li Z. -W, Wolfer DP, Lipp HP, Rülicke T, Brandner S, Aguzzi A, Weissmann C. Behavioral and anatomical deficits in mice homozygous for a modified ß-amyloid precursor protein gene. Cell 79:755-765, 1994

7. Wolfer DP, Henehan-Beatty A, Stoeckli E, Sonderegger P, Lipp HP. Distribution of TAG-1/axonin-1 in fibre tracts and migratory streams of the developing mouse nervous system. J Comp Neurol 345:1-32, 1994

1990-1993

6. Lipp HP, Wolfer DP, Qin WX, Klee CB, Heizmann CW. CBP-18, a Ca2+-binding protein in rat brain: Tissue distribution and localization. J Neurochem 60:1639-1649, 1993

5. Dell'Omo G, Wolfer DP, Lipp HP, Alleva E. Impaired acquisition of swimming navigation in adult mice exposed prenatally to oxazepam. Psychopharmacology 111:33-38, 1993

4. Wolfer DP, Lipp HP. A new computer program for detailed off-line analysis of swimming navigation in the Morris water maze. J Neurosci Meth 41:65-74, 1992

3. Gruber D, Waanders R, Collins RL, Wolfer DP, Lipp HP. Weak or missing paw lateralization in a mouse strain (I/LnJ) with congenital absence of the corpus callosum. Behav Brain Res 46:9-16, 1991

2. Schöpke R, Wolfer DP, Lipp HP, Leisinger-Trigona MC. Swimming navigation and structural variations of the infra-pyramidal mossy fibers in the hippocampus of the mouse. Hippocampus 1:315-328, 1991

1. Haber SN, Wolfer DP, Groenewegen HJ. The relationship between ventral striatal efferent fibers and the distribution of peptide-positive woolly fibers in the forebrain of the rhesus monkey. Neuroscience 39:323-338, 1990