Institute of Anatomy UZH and IBWS ETH Zurich
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Information for Students
I am emeritus since 01.08.25 and no longer involved in teaching. Materials relevant to my courses
of the semesters winter 2005/6 - spring 2025 can be found in the archive. Parts of the online quiz still relevant for repetition exams are here.
Research
My research group is no longer active. Our field of research was cognitive and behavioral neuroscience. My group used mouse models to gain a better understanding of the role of the hippocampus in the control of behavior under normal and disease conditions. To this end we were also developing new approaches for automated high throughput analysis of behavior in the home cage. A further line of research investigated the effects of environment and exercise on hippocampal plasticity and cognitive function.
Selected publications:
[ Google Scholar | ResearcherID ]
Böttger EC, Santhosh Kumar H, Steiner A, Sotirakis E, Thiam K, Isnard Petit P, Seebeck P,Wolfer DP, Shcherbakov D, Akbergenov R. Translational error in mice increases with ageingin an organ-dependent manner. Nat Commun 16:2069, 2025Brilkova M, Nigri M, Kumar HS, Moore J, Mantovani M, Keller C, Grimm A, Eckert A, ShcherbakovD, Akbergenov R, Seebeck P, Krämer SD, Wolfer DP, Gent TC, Böttger EC. Error-prone proteinsynthesis recapitulates early symptoms of Alzheimer disease in aging mice.Cell Rep 40:111433, 2022Nigri M, Åhlgren J, Wolfer DP, Voikar V. Role of environment and experimenter in reproducibilityof behavioral studies with laboratory mice. Front Behav Neurosci 16:e835444, 2022Shcherbakov D, Nigri M, Akbergenov R, Brilkova M, Mantovani M, Petit PI, Grimm A, Karol AA,Teo Y, Sanchón AC, Kumar Y, Eckert A, Thiam K, Seebeck P, Wolfer DP, Böttger EC.Premature aging in mice with error-prone protein synthesis. Sci Adv 8:eabl9051, 2022Luo W, Egger M, Domonkos A, Que L, Lukacsovich D, Cruz-Ochoa NA, Szocs S, Seng C,Arszovszki A, Sipos E, Amrein I, Winterer J, Lukacsovich T, Szabadics J, Wolfer DP, Varga C,Földy C. Recurrent rewiring of the adult hippocampal mossy fiber system by a singletranscriptional regulator, Id2. PNAS 118:e2108239118, 2021Richter MC, Ludewig S, Winschel A, Abel T, Bold C, Slazburger LR, Klein S, Han K, Weyer S,Fritz AK, Laube B, Wolfer DP, Buchholz CJ, Korte M, Müller UC. Distinct in vivo role of APPsαversus APPsβ for spine density, synaptic plasticity and cognition. EMBO J 37:e98335, 2018Hick M, Herrmann U, Weyer SW, Mallm P, Tschäpe J, Borgers M, Mercken M, Roth R, Draguhn A,Slomianka L, Wolfer DP, Korte M, Müller UC. Acute function of secreted Amyloid PrecursorProtein fragment APPsα in synaptic plasticity. Acta Neuropathol 129:21-37, 2015